PANTS Clinical Study published in THE LANCET Gastroenterology & Hepatology



The much anticipated prospective UK study aimed at investigating the mechanisms of anti-TNFa blocker treatment failure in patients with active luminal Crohn's disease has been published today in THE LANCET Gastroenterology and Hepatology. The 1610 patient study included inter alia therapeutic drug monitoring by measuring serum Drug Levels (Infliximab and Adalimumab) and Total Anti-drug antibodies to those drugs, in order to unveil risk factors for the prediction of primary non-response, non-remission and immunogenicity.


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