IDKmonitor Golimumab Free Anti-drug antibody ELISA 96 wells
Therapeutic Drug Monitoring
Golimumab is a recombinant protein that has the potential to induce humoral immune responses and lead to anti-drug antibody formation; a major cause of loss of response.
These Anti-drug antibodies bind and neutralise the TNFα inhibitors accelerating their clearance and reduces the efficacy of the drugs. Monitoring the efficacy of TNFα inhibitors may help clinicians schedule a successful individualised treatment strategy for their patients.
Free Anti-Golimumab Antibody ELISA
Free anti-drug antibody ELISAs ("drug sensitive assays") enable the detection of anti-drug antibodies that are not bound to other proteins or therapeutic drugs.
IDKmonitor® Golimumab Free Anti-drug Antibody ELISA is a qualitative assay that detects human antibodies against Golimumab in EDTA plasma and serum samples by capturing the anti-Golimumab antibodies on the microplate which is coated with Golimumab F(ab)2 fragments.
Detects free anti-Golimumab Antibodies in Serum and Plasma
Microplate coated with highly specific Golimumab F(ab)2 fragments
1 calibrator, 2 controls
Capacity for 45 samples in duplicate
Assay time 130 minutes
Automatable on ELISA automates (e.g. Dynex DS2)
Supports the investigation of primary non response and loss of response to Golimumab
Drug sensitive assay only detects free anti-golimumab antibodies (those not bound to golimumab)
May help predict long term outcome of disease in patients with sub-therapeutic golimumab levels
Available via reference laboratories in UK
Applicable to Gastroenterology, Rheumatology
+2 to +8