IDKmonitor Golimumab Drug Level ELISA 96 wells
Therapeutic Drug Monitoring
The IDKmonitor Golimumab Drug Level ELISA kit is a microplate-based quantitative enzyme linked immunosorbent assay (ELISA) for the determination of free Golimumab from plasma or serum samples.
The Golimumab ELISA is based on a sandwich enzyme immunoassay technique with a Golimumab specific capture antibody adsorbed on a microplate and a detection antibody labeled with horseradish peroxidase (HRP).
This test is intended to quantify the amount of free drug (Golimumab) to evaluate the efficacy of drug and to investigate Primary non-response and loss of response.
Being able to stratify patients according to whether they are likely to benefit from their Golimumab treatment has both clinical and economic advantages because not all patients respond equally to Golimumab.
Some patients will respond well with fewer symptoms with a reduction in inflammatory biomarkers (e.g. faecal calprotectin) and endoscopic scores, while others will fail to respond during the induction phase of treatment, or lose response over time.
IDKmonitor® assays from BIOHIT HealthCare are highly specific for the target drug and are used widely for routine clinical and research applications. The IDKmonitor® Golimumab Drug Level ELISA helps:
Assess risk of and manage primary non-response
Predict the long term outcome and identify loss of response
Predict response to anti-TNFα therapy withdrawal
Predict efficacy of re-initiating therapy after drug holiday
Direct the switching to another class of drug
The IDKmonitor® Golimumab Drug Level ELISA is for the quantitative determination of free therapeutic TNFα antibodies (Golimumab (e.g. SIMPONI®)) in EDTA plasma and serum. The assay detects and quantifies free Golimumab from a sample by capturing it using specific monoclonal anti-Golimumab antibody that coats the plate.
The assay is widely available throughout the UK and Ireland to both routine clinical laboratories as well as for research applications. Please contact us for your nearest test reference laboratory.
Quantifies free Golimumab drug levels in Serum and Plasma
Microplate coated with highly specific anti-Golimumab Ab
6 calibrators, 2 controls
Capacity for 40 samples in duplicate
Reportable range 4.15-225 ng/ml
Total incubation time 130 minutes
Automatable on ELISA automates (e.g. Dynex D2)
Highly specific quantification of Golimumab
Helps predict Primary non-response, loss of response, non remission
Available via reference laboratories in UK
Applicable to Gastroenterology, Rheumatology
+2 to +8