IDKmonitor Etanercept Free Anti-drug antibody ELISA 96 wells
Therapeutic Drug Monitoring
Etanercept is a recombinant protein that has the potential to induce humoral immune responses and lead to anti-drug antibody formation; a major cause of loss of response.
These Anti-drug antibodies can bind and neutralise the drug accelerating its clearance and reducing its efficacy. Monitoring the efficacy of Etanercept may help clinicians schedule a successful individualised treatment strategy for their patients.
Free Anti-Etanercept Antibody ELISA
Free anti-drug antibody ELISAs ("drug sensitive assays") enable the detection of anti-drug antibodies that are not bound to other proteins or therapeutic drugs.
IDKmonitor® Etanercept Free Anti-drug Antibody ELISA is a quantitative assay that detects human antibodies against Etanercept in EDTA plasma and serum samples by capturing the anti-Etanercept antibodies on the microplate which is coated with Etanercept binding domains.
Detects free anti-Etanercept Antibodies in Serum and Plasma
Microplate coated with highly specific Etanercept fragments
1 calibrator, 2 controls
Capacity for 45 samples in duplicate
Assay time 130 minutes
?Automatable on ELISA automates (e.g. Dynex D2)???
Supports the investigation of primary non response and loss of response to Etanercept
Drug sensitive assay only detects free anti-Etanercept antibodies (those not bound to Etanercept)
May help predict long term outcome of disease in patients with sub-therapeutic Etanercept levels
Applicable to Rheumatology
+2 to +8