The BIOHIT Pepsinogen I ELISA is part of the GastroPanel® family of assays - a simple blood test for Primary Care that aids the diagnosis of dyspepsia by effectively ruling out diseases of the gastric mucosa characterised by Helicobacter pylori (H.pylori) infection and atrophic gastritis.
Pepsinogen I concentration in blood reflects the mucosal structure and function of the gastric body (corpus). Infection with Helicobacter pylori or autoimmune disease can cause moderate to severe atrophy of stomach body mucosa (atrophic gastritis of corpus). Then follows a fall in blood Pepsinogen I levels below 30 µg/l, and results in an acid-free or low-acid stomach. In contrast, if the patient has inflammation of stomach body mucosa, but no atrophy (gastritis of corpus), the blood Pepsinogen I concentration tends to increase to some extent.
The Pepsinogen I/II ratio is used together with Pepsinogen I value for diagnosis of atrophy of the gastric body mucosa (atrophic gastritis of corpus). In the case of atrophic gastritis of corpus, the ratio decreases below 3.
Use Pepsinogen I as part of the complete GastroPanel® to help diagnose:
Healthy stomach mucosa. When the stomach mucosa is healthy, the cause of stomach symptoms is most likely to be functional dyspepsia or disease outside the stomach.
H. pylori infection
Atrophic gastritis (severely damaged and dysfunctional stomach mucosa) and specifically the location of the disease, e.g. corpus, antrum, or both mucosa
GastroPanel® consists of four ELISAs and can be set up in any local laboratory or can be requested via BIOHIT's Service Laboratory.