The BIOHIT Helicobacter pylori IgG ELISA is part of the GastroPanel® family of assays - a simple blood test for Primary Care that aids the diagnosis of dyspepsia by effectively ruling out diseases of the gastric mucosa characterised by Helicobacter pylori (H.pylori) infection and atrophic gastritis.
Helicobacter pylori nests on gastric mucosa of an infected person. It is usually transmitted in childhood and causes an infection (inflammation, gastritis). If left untreated, the infection becomes chronic and persists for life. The infection is very common in older age groups and it increases the risk of duodenal or gastric ulcers.
For some patients, Helicobacter pylori infection causes gastric mucosal atrophy and dysfunction (atrophic gastritis). Atrophic gastritis is usually asymptomatic, and it causes the stomach to become acid-free, where oral microbes are able to live and produce a carcinogenic acetaldehyde from sugars and alcohol. Although Helicobacter pylori infection can be treated, an acid-free stomach rarely recovers, and this poses a significant risk of developing stomach and oesophageal cancer.
Acid-free stomachs are associated with malabsorption of vitamin B12, iron, magnesium, calcium, zinc and certain drugs. Calcium deficiency causes osteoporosis and deficiency of vitamin B12 can cause anaemia, dementia, depression and peripheral nervous system damage. Performing Endoscopy on individuals suffering from atrophic gastritis may help to diagnose stomach cancer at an early stage, when the prognosis of gastric cancer significantly improves.
Infection with Helicobacter pylori is likely when the antibody level is more than 30 EIU. When eradication therapy of Helicobacter pylori is completed, it may take several months before the antibody levels return to normal after successful eradication therapy.
Use H. pylori IgG as part of the complete GastroPanel® to help diagnose:
Healthy stomach mucosa. When the stomach mucosa is healthy, the cause of stomach symptoms is most likely to be functional dyspepsia or disease outside the stomach.
H. pylori infection
Atrophic gastritis (severely damaged and dysfunctional stomach mucosa) and specifically the location of the disease, e.g. corpus, antrum, or both mucosa
GastroPanel® consists of four ELISAs and can be set up in any local laboratory or can be requested via BIOHIT's Service Laboratory.